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Thereafter, some proline residues are hydroxylated in the endoplasmic reticulum by prolyl 4-hydroxylase in the presence of oxygen, ascorbic acid, -ketoglutarate, and Fe 2+ to form 4-hydroxyprolyl residues (Gorres and Raines 2010)

2018;41:e1134

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Head injury treatment with healthy and advanced dietary supplements: a pilot randomized controlled trial of the tolerability, safety, and efficacy of branched chain amino acids in the treatment of concussion in adolescents and young adults