At higher, maximally efficacious semaglutide doses, food intake suppression appears to approach a physiological lower limit of approximately 1 g/day, beyond which additional anorectic effect is minimal [27]
Discussion As diets high in protein are theoretically advantageous for patients with T2D and obesity due to their satiating properties compared with carbohydrate- and lipid-rich meals [25,26,27], specific amino acids selected for their appetite-reducing and GLP-1 stimulating effect may represent an approach for nutritionally based modulation of GLP-1 secretion
The GLP-1R is a G-protein coupled receptor that has wide tissue expression, including in the brain, the wall of the portal vein near the hilus of the liver, and arteries and arterioles from various organs (kidney, heart, pancreas, and intestine) [18]
Nature (2018)
These medications are most effective when used in combination with a reduced-calorie diet and regular physical activity
