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Among the docked poses, mh-Tyr-C3G (~ 65.4%), mh-Tyr-EC (~ 75.5%), mh-Tyr-CH (~ 62.2%), and mh-Tyr-ABR (~ 59.66%) exhibited a steep drop in the Eigen fraction corresponds to the early five eigenvalues by comparison to apo-mh-Tyr structure (58.65%)

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MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: A randomised, controlled, double-blind, ascending dose and phase 2a study