It's important to note that none of these improve outcomes, and niacin in particular worsens outcomes and insulin resistance, see the niacin article
Picard K, Griffiths M, Mager DR, Richard C
A GP, pharmacist, or specialist clinician can: Review your current medication list for potential interactions, particularly with diabetes medications, anticoagulants, thyroid treatments, and hormonal contraceptives Assess your nutritional status and advise on appropriate supplementation only where deficiencies are confirmed Monitor for adverse effects such as hypoglycaemia, gastrointestinal disturbance, or unexpected changes in blood pressure or heart rate Refer you to appropriate NHS services , including Tier 3 weight management programmes, if you are seeking structured support for obesity Discuss contraception and family planning , as retatrutide should not be used during pregnancy or breastfeeding
Safety Profile The most commonly reported adverse events were gastrointestinal in nature, including nausea, diarrhea, vomiting, and constipation
Starting Treatment: Should You Begin During or After GLP-1 Medication