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Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis

The SUSTAIN-6 trial noted cholelithiasis in 1.7% of semaglutide patients versus 1.3% of placebo, a small but directionally consistent finding

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Clinical Evidence: Why Doctors Prescribe Semaglutide Off-Label The STEP trials, conducted between 2020 and 2021, demonstrated that semaglutide 2.4 mg weekly produced an average weight loss of 10 to 17% of body weight over 68 weeks in patients without diabetes