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No evidence of carcinogenicity with metformin was found in either male or female mice

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"If were seeing that were already seeing downstream effects of weight, were going to be more likely to want to treat with a GLP-1." She continued, Im definitely reluctant to start it if there are not those clear risk factors, however, it may be completely appropriate for an adolescent who has been trying to lose weight and has not had any success. The same Evernorth Research Institute report stated, A subgroup analysis reveals that weight loss is the main reason younger generations are turning to GLP-1 therapies. McCauley said GLP-1s need to be used in tandem with lifestyle changes like improved diet and exercise, particularly strength training

Pharmacological interventions may be appropriate if lifestyle measures prove insufficient