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Most of these trials measured endpoints like the status of antioxidant enzymes including GPx and inflammatory cytokines in the serum, reduction of radiotherapy side effects (like mucositis, myelosuppression, and diarrhea), and overall improvement of the quality of life

Part of this effect is mediated by the upregulation of miR-125b, which amplifies copper-dependent pro-inflammatory signaling [209]

Endothelial dysfunction, vascular resistance, hypertension, and arterial wall inflammation are more likely to occur in patients with pre-existing microvascular damage, such as that caused by insulin resistance (23)