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This hormone performs several key functions: it stimulates insulin secretion, reduces glucagon secretion, and slows gastric emptying, all of which contribute to lower blood sugar levels

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Therefore, published preclinical work reported preferential activation of the human AMY1 receptor, with substantially lower activation of AMY3 and the calcitonin receptor in the tested systems

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For example, one study found that 52 weeks after stopping once-weekly semaglutide injections, participants had regained 66% of their prior weight loss