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Eight studies had low risk of bias (43, 5557, 61, 64, 71, 72), 11 studies had moderate risk of bias (44, 48, 50, 54, 58, 63, 65, 68, 74, 75, 79) and 22 studies had high risk of bias (4547, 49, 5153, 59, 60, 62, 66, 67, 69, 70, 73, 7678, 80)

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Furthermore, a recent resting-state functional magnetic resonance imaging (MRI) analysis of 18 women with obesity or polycystic ovary syndrome (PCOS) randomized to either 16-week semaglutide or placebo showed no significant changes in brain regions associated with depression and suicidality 177