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Because (i) tyrosinase is not convincingly found in the human SN, (ii) TH, unlike tyrosinase, does not oxidize DOPA, DA and NE, and (iii) free DA and NE in the cytoplasm are easily autoxidized to DAQ and NEQ, the pathway for the biosynthesis of the melanic portion of NM in human brain appears to be (Fig

Recently, a combined research group from Sweden and the United States demonstrated for the first time the presence of activated glia, resulting in active neuro-inflammation in the brains of fibromyalgia patients

Persistent nausea may further reduce food intake beyond the medication's appetite-suppressing effects, and gastrointestinal distress can disrupt sleep quality, leading to daytime tiredness

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