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In a study with more than 6,000 people participating in one of two weight loss programs, those on a 500 calorie per day diet for three months, followed by nine months of weight maintenance, were three times more likely to need hospitalization for symptomatic gallstones or cholecystectomy for gallstones than those who started with a 1,2001,500 calorie per day diet

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This has led researchers to investigate its potential implications in neurodegenerative disease models and brain organoid development, where cellular resilience and synaptic remodeling are critical research topics