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In acute animal injury models, repair cascade activation is relatively rapid

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11 In addition, Medina and colleagues found higher frequency and severity of immune-related adverse events associated with the combination of checkpoint inhibitors compared with single-agent checkpoint inhibitor therapy

Under basal or lipotoxic conditions, G9a represses autophagy by enriching H3K9me2 at the promoters of LC3B, WIPI1 , and DOR , thereby silencing their transcription and reducing their autophagic activity

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