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However, most of these efforts have been plagued with significant adverse effects and/or limited efficacy which has resulted in the withdrawal and discontinued use for the majority of these medications [5]

Both excitatory and inhibitory synaptic genes show decreased expression with age and are positively correlated with BDNF and NTRK2 expression and negatively correlated with dominant-negative truncated NTRK2 level

The study, involving 384 participants across 28 clinics, proved that TENS is as effective as FDA-approved medications but with a dose-dependent benefit that doesnt fade over time

2021;109:461-472.e5