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In 2024, we also saw unprecedented willingness by large numbers of patients to pay out of pocket, even in European markets, as public coverage of AOMs is still limited, at best, and more often non-existent

136139 Consistent with these characteristics causing kidney damage through hypoxia, the db/db mouse shows increased glomerular expression of hypoxia-inducible factor 1 (HIF-1) and other genes involved in oxidative stress

Eur J Pharmacol 429:195207