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Clinical trials that led to regulatory approval did not identify back pain as occurring at significantly higher rates in treatment groups compared to placebo

The specific biomarkers focused on were adiponectin, leptin, IL-6, TNF-, plasminogen activator inhibitor-1 (PAI-1), brain natriuretic peptide (BNP), and high-sensitivity C-reactive protein (hs-CRP)

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doi: 10.1097/PSY.0000000000000214

How Semaglutide Works and Why It Complements Metformin Semaglutide is a GLP-1 receptor agonist that activates receptors throughout the brain and gut responsible for appetite suppression, satiety signaling, and glucose regulation