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The European Food Safety Authority (EFSA) further set a conservative acceptable daily intake (ADI) of 322 mg/day for adults

The 68-week clinical trial showed that individuals with obesity or excess weight with a related medical problem lost an average of 14.9% of their body weight (35 pounds) at 68 weeks

Hypomagnesemia recurred if PPI therapy was re-introduced[226] Another recent review of 4 cases examined the clinical consequences and mechanisms of electrolyte disorders that resulted from the elderly patients taking a PPI for a period of 1 to 13 years.[227] They developed severe low magnesium levels with low calcium levels, hypoparathyroidism (low parathyroid hormone), and extremely low urinary calcium and magnesium excretion

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