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Cycle Length 8 weeks is recommended

The healthcare provider may also consider whether a gradual tapering off of Saxenda before starting Wegovy is appropriate or whether it's safe to switch directly from one to the other

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Semaglutide: Nausea, vomiting, diarrhea, constipation Tirzepatide: Nausea, vomiting, diarrhea, constipation, potential injection site reactions Managing Side Effects in Clinical Practice In clinical practice, managing side effects is a crucial part of patient care

This in turn initiates the release of neurotransmitters gamma aminobutyric acid (GABA), serotonin (5-HT) and noradrenaline into the presynaptic space as consequence of raised [Ca2+]i [2540]