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Also studied was the combined application of N G -nitro-L-arginine methylester (L-NAME) (5 mg/kg i.v.), a competitive inhibitor of endothelium nitric oxide (NO)-generation and the NO-precursor L-arginine (200 mg/kg i.v.) (D-arginine was ineffective)

Loren Pickart in 1973, delivers copper directly to those activated fibroblasts

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