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Glucose-6-phosphate dehydrogenase deficiency

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Neutrophil-derived proteolytic enzymes (i.e., myeloperoxidase and elastase) may also be involved in the initiation of AT inflammation (132)

While genetic association studies for common variants in the GDNF gene have been underpowered for tinnitus, plasma biomarker studies have identified GDNF among top circulating proteins associated with constant tinnitus, though these associations did not survive strict multiple testing corrections (Amanat et al., 2021