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It accelerates wound healing, promotes angiogenesis (new blood vessel formation), and reduces inflammation at the cellular level

A placebo-controlled trial shows that 6mg of supplemental melatonin decreases inflammatory markers (TNF-alpha, IL-6, and CRP) in obese women.[ref] A meta-analysis of a bunch of studies found that melatonin consistently reduces CRP and IL-6 in people with metabolic syndrome.[ref] Several studies have shown that supplemental melatonin (along with diet) increases weight loss.[ref][ref] Diabetes: Adding melatonin with exercise cures insulin resistance, hypertension, and fatigue in an animal model of diabetes.[ref] But what about humans

In 2023, researchers conducted a systematic review to identify studies on the effect of vitamin K supplementation on blood sugar-related parameters and vitamin K intake on diabetes risk

Pigmentation and melanin signalling studies

It requires no prescription and is available in various strengths from multiple brands