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Clathrin Box mutations decrease Ent1-Abp1 endocytic events To evaluate the impact of mutations in the Clathrin boxes during endocytosis, we measured lifetime of Ent1 and Ent2 proteins endogenously tagged with mNeonGreen in the presence of Abp1-mTurquoise2 at endocytic sites by TIRF microscopy
A Phase IIb trial of mRNA-4157 in combination with pembrolizumab for patients with resected high-risk melanoma showed that this combination therapy prolonged recurrence-free survival compared with pembrolizumab monotherapy and had a manageable safety profile
No new safety signals appeared between weeks 24 and 48, suggesting the medication does not cause delayed-onset problems during the first year of use
10.1007/s12031-015-0526-5 128 LiL.ZhaoG
However, evidence of the efficacy of enhanced control of glycemia in preventing neuropathy is stronger in patients with type 1 diabetes than in those with type 2 diabetes (73)
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