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GLS expression is increased post-castration in LNCaP and LAPC4 xenografts (61), and pharmacological inhibition of GLS1 reduces the tumor burden in PC3, but not LNCaP xenografts (61), highlighting the dependency on glutamine metabolism in AR-negative, hormone-insensitive prostate cancer (61)

A previous report demonstrated respiratory failure due to morbid obesity and the need for long-term mechanical ventilation in a patient with PWS and concluded that weight reduction was important for weaning off a mechanical ventilator [5]

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Adverse Reactions/Side Effects In most cases, methylcobalamin is nontoxic, even in large doses

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