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reported that GPX3 expression is upregulated in the hearts of mice under hyperglycemic conditions and plays a crucial role in protecting cardiomyocytes from hyperglycemia-induced oxidative stress in the cardiac tissue of diabetic mice [144]

Notes: Blue rectangles illustrate metabolites, blue circles represent enzymes, orange circles are dietary cofactors, green star shapes show garlic and other polysulfide-containing nutrients, red rectangle indicates H2S, and purple rectangles represent direct and indirect influence of H2S on vasodilation and blood pressure

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however, these situations disrupt this balance