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Hydrogen per- and tri-sulfide (H 2 S 2 and H 2 S 3 ) have recently emerged as novel signaling molecules related to hydrogen sulfide (H 2 S), which regulates neuronal transmission, vascular tone, cytoprotection, anti-inflammation, and oxygen sensing 6,7,8,9,10,11,12,13

SARS-CoV-2-infected patients with COVID-19 disease show alterations in the glucoseinsulin axis leading to hyperglycemia, hyperinsulinemia and insulin resistance, increased oxidative/nitrosative stress, and significantly decreased vitamin D, thiols, total-antioxidant-capacity, GSH and selenium (Soto et al., 2022)

The APX forms differ in substrate affinities, dimer formation, and the presence of transmembrane domains

The format is convenient and easy to handle during daily bench work

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