Potential role of nitric oxide in contraction-stimulated glucose uptake and mitochondrial biogenesis in skeletal muscle
A 2022 clinical study found that an injectable GLP-1 agonist given during IBS flare-ups significantly reduced pain intensity compared to placebo twice as many patients achieved meaningful pain relief with the GLP-1 analog than with placebo
Common side effects Urinary tract infection (UTI) Vaginal yeast infection (females) Upper respiratory tract infection Increased cholesterol or triglycerides Increased urination Other mild side effects Nausea Genital yeast infection (males) Joint pain Increased thirst Weight loss Serious side effects Diabetic ketoacidosis (DKA): nausea, vomiting, abdominal pain, fatigue, increased thirst, dry mouth, fruity breath, breathing difficulty Dehydration/hypotension: dizziness, lightheadedness, reduced urine output Hypoglycemia (with insulin or sulfonylureas): anxiety, shakiness, confusion, fatigue, hunger, rapid heartbeat Severe kidney infections (pyelonephritis, urosepsis): fever, chills, back pain, painful urination Necrotizing fasciitis (Fourniers gangrene): severe genital/perineal pain, swelling, redness Amputations (rare): new foot/leg sores, ulcers, infections Allergic reactions: hives, rash, facial/lip/tongue swelling, breathing difficulty Pancreatitis: upper abdominal pain radiating to back, fever, nausea, vomiting Who should not take Jardiance
Models of weekly outcomes used intention-to-treat principles (all 48 randomized participants included)
Theres millions of people getting it and theyre not morbidly obese or diabetic
