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Metabolic adaptation, dose tolerance, and lifestyle drift are common culprits

[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Morgavi D.P., Riley R.T

Additionally, the proline-rich domain contains five PXXP motifs, which participate in interactions between p53 and various proteins

Giving them more frequently than the established schedule is a form of over-treatment that is not supported by evidence and can strain healthcare resources (nurses time, clinic space, and medication supplies)