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For instance, in mouse embryonic stem cells, targeted disruption of glucose-6-phosphate dehydrogenase, which is the rate-limiting enzyme in the pentose phosphate pathway, the predominant metabolic pathway for the generation of NADPH (a cofactor of GR), renders cells extremely sensitive to H 2 O 2 -induced cell death 34

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The use of selective CRF receptor subtype agonists and antagonists as well as transgenic animal models established the primary role of CRF 1 receptor in driving the stress-related HPA, behavioral, autonomic and visceral responses (Turnbull and Rivier, 1997

Peptide therapy should always be approached carefully and under professional medical supervision

doi: 10.1186/s12967-020-02356-2 22 CorbittMEaton-FitchNStainesDCabanasHMarshall-GradisnikS