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Endothelium-dependent contractions and endothelial dysfunction in human hypertension

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Lenzi A, Lombardo F, Sgro P, Salacone P, Caponecchia L, Dondero F, et al

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Briefly, a closed testing procedure that operated based on an overall significance level of alpha = 0.05 was allocated to the initial test, which was either a test of non-inferiority for SEM 14 mg compared to active comparators (empagliflozin in PIONEER 2 and sitagliptin in PIONEER 3) or a test of superiority for SEM 14 mg compared to placebo (PIONEER 1, 4, and 8)