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Rotor syndrome was found in a study of eight families to be linked with mutations in genes that are believed to affect the functioning of the above-mentioned OATP1B1 and OATP1B3 proteins

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Preclinical and phase 1/2 showed that inhibition of potassium flow through the Gardos channel increased Hb levels and decreased hemolysis (ClinicalTrials.gov Identifier: NCT00040677)

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