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Following oxidative insult, the activity of the oxidative branch increases to direct the non-oxidative branch toward resynthesizing F6P, which is then converted back to G6P to replenish the oxidative branch, allowing enhances for NADPH generation

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A 2023 study published in the Journal of Hepatology reported on a Phase IIa trial aimed at evaluating the efficacy and safety of efinopegdutide in patients with NAFLD, comparing it to semaglutide

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