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The necessity of appropriate pH in a biological system is crucial as it helps maintaining biochemical equilibria, correct levels of proton dissociable groups and maintain the cell pH at near neutral all the time

On the other hand, evidence indicates that estradiol also plays an important role in differentiating the human brain during early prenatal stages and even after birth (Gillies and McArthur, 2010)

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Less consistent evidence across analyses were found for an association between higher C3 levels and an anhedonic symptom profile previously linked with inflammation and neurobiological reward processes