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Adverse reactions reported in at least 3% of REPATHA-treated patients, and more frequently than in placebo-treated patients are shown in Table 1

Science 375, 12541261

10.3390/antiox10101503 40 LnonM.KeN.SzadyC.SakhtahH.RenG.MantaB.et al (2020)

Factors influencing recommended serving size Body weight: Individual factors, including body size and wellness goals, may influence recommendations from a healthcare provider

In addition, TMAO was suggested to activate NFB, likely through a G-protein coupled receptor G signaling pathway in endothelial cells and vascular smooth muscle cells, leading to enhanced expression of proinflammatory cytokines and leukocyte adhesion to endothelial cells in vitro (Seldin et al., 2016)