His own commercial formulations at Skin Biology never used nano-carriers
Cantin, A.M., North, S.L., Hubbard, R.C
A compounding pharmacy serving a single dermatology clinic with a topical GHK-Cu cream is governed by 503A
Research has demonstrated that GHK-Cu treatment increases production of collagen (particularly type I and type III collagen, the predominant structural collagens in skin and connective tissues), glycosaminoglycans (including hyaluronic acid, which provides hydration, volume, and biochemical signaling in skin), decorin (a small proteoglycan involved in collagen fibril organization and growth factor regulation), and other matrix molecules critical for tissue structure and function
If you notice redness, itching, peeling, stinging, or bumps, reduce frequency or stop use