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Canagliflozin mitigates ferroptosis and ameliorates heart failure in rats with preserved ejection fraction

It will be very useful in a clinical setting and in assisted living senior facilities as a wound dressing, especially for diabetic and ischemic wounds

Results: The CLP-induced SAE model showed significant hippocampal damage, microglial activation, cognitive deficits, and increased levels of pro-inflammatory cytokines, ROS, and MDA

Results based on a randomized 12-week human clinical study (Study A, N=56)

The peptide downregulates or inhibits key lipogenic enzymes including fatty acid synthase and acetyl-CoA carboxylase, which are responsible for converting excess dietary carbohydrates and other substrates into fatty acids for storage