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A 10-year longitudinal follow-up of a retrospective cohort comprising 159 patients with PCOS treated with metformin reported that the total testosterone and androstenedione decreased to 15.4 47.9% and 11.3 46.4% within first year, with further decrease in total testosterone and androstenedione to 37.8 61.8 and 24.8 40.5% at the fifth year of the follow-up (38, 39)