144 This can pose challenges in achieving therapeutic serum concentrations of agents such as anti-TNF therapies 17 and thioguanine metabolites
In general, benchmark chemicals (Akemi, Acrylate copolymer, BE PVM/MA, PHMG, and BAC) and reference materials (LPS, Isoproterenol, and TNF-) produced differentially modulated cytokines and chemokines release over the 12-day experimental period (Table 4
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