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Heart disease, uncontrolled hypertension, an overactive thyroid, glaucoma, and a history of substance use are all reasons to choose a different path, which is why we recommend an EKG and a full history before the first dose, then monitor blood pressure and response over the course of treatment

J Pharmacol Exp Ther 318:9098

FOXO transcription factors play a crucial role in the regulation of processes related to aging and longevity, with increasing evidence suggesting their significance in the pathogenesis of neurodegenerative diseases (NDDs)

doi: 10.1159/000053183

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