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Aging 36,1604.E11604.E6

M.KazanK.WilsonI.AndersonJ

(2013) 4:e33

249,250 Acute systemic injections of the bacterial antigen lipopolysaccharide (LPS) in mice induces diffuse inflammatory changes in the CNS and mimics this sickness behaviour and is often used as a model to study effects of inflammation on CNS functions

Recent studies using isotopic tracer techniques have quantified the relative contributions of these pathways, revealing that mitochondrial O 2 production initiates about 45% of hyperglycemia-induced damage, while PKC activation and AGE formation account for 30% and 25%, respectively (Pardina et al., 2024)