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The beauty is in the selectivity: it triggers GH release without the cortisol spike or prolactin surge that some other peptides cause

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Metformin has been considered as a treatment option for PCOS

Stat Methods Med Res

Recent work suggested that the reduction in both food intake and body weight observed in response to combined treatment with GLP-1RAs and PYY 3-36 results in synergistically-enhanced activation of discrete hypothalamic and brainstem circuits that regulate appetite, including the arcuate nucleus (ARC), the paraventricular nuclei of the hypothalamus (PVNs), the central nucleus of the amygdala (CeA), and the hindbrain (AP/NTS) 10,12,21,44