however, the exact mechanism of action is unknown
Individual response to GLP-1 medications varies meaningfully variants in GLP1R (the GLP-1 receptor itself), GIPR (which matters specifically for tirzepatide's dual-agonist mechanism), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) are associated with different weight-loss curves and different tolerability profiles
doi: 10.2174/0929867321666140706130807
The hormone acts through GLP-1 receptors (GLP-1R), which are G-protein coupled receptors distributed throughout the body, including various regions of the central nervous system
FDA ramps up its pushback against compounded GLP-1s In a move that will delight Novo Nordisk and Eli Lilly, the FDA has sent warning letters to 30 telehealth companies, accusing them of illegally marketing compounded GLP-1 agonist formulations