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Methylsulfonylmethane, or MSM, provide a rich source of bioavailable sulphur, which supports the formation of important nutritional elements including glutathione, cysteine, and methionine MSM may support the formation of healthy connective tissue

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doi: 10.1002/adma.200701205

The complex three-dimensional structure required for receptor binding can be disrupted by environmental factors, leading to reduced biological activity