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Preclinical research progress Pharmacokinetic optimization: By glycosylation (PEGylation) or liposome encapsulation to extend the half-life, addressing the problem of rapid metabolism of natural peptides

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Combined with clinical assessment, this personalization may improve both treatment adherence and outcomes

Peripheral neuropathy may take 36 months to improve, and some patients experience incomplete recovery, particularly if treatment was delayed

It will require clinical trials by independent entities to delineate the true effectiveness and side effect profile of this and all new medications. Following the results of earlier trials, Novo Nordisk submitted a New Drug Application to the Food and Drug Administration (FDA) in December 2025 for the use of CagriSema to assist and maintain weight loss alongside diet and exercise adjustments