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25 Other factors contributing to the hepcidin suppression include platelet-derived growth factor-BB, which is expressed in various cell types exposed to EPO, downregulating the transcription factors cyclic adenosine monophosphate response element binding protein (CREB) and CREB-H

Plasma His showed significant positive correlations with milk Ala and Asp, potentially through His transamination to Ala and Asp's role in urea cycle-mediated ammonia detoxification (41)

They frequently present decreased caloric intake and increased metabolic requirements

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