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These questions keep researchers awake at night, and for good reason

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Hence, the failure of leptin to decrease food intake and body weight in obesity may result from high leptin levels producing changes that act downstream of the initial steps in leptin signalling to create a functional ceiling for leptin action The available data suggest that leptin functions primarily in defence against decreased body weight rather than in limiting increases in body weight Abstract Obesity represents the single most important risk factor for early disability and death in developed societies, and the incidence of obesity remains at staggering levels

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