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Whilst personality changes are not established side effects, your concerns deserve proper clinical assessment

[1] Carnitine shuttle system [edit] The free-floating fatty acids, released from adipose tissues to the blood, bind to carrier protein molecules known as serum albumin that carry the fatty acids to the cytoplasm of target cells such as the heart, skeletal muscle, and other tissue cells, where they are used for fuel

If using oral contraceptives with tirzepatide, be aware that delayed gastric emptying may reduce contraceptive effectiveness

Anders, S

By improving fat transport into mitochondria, it can make exercise feel easier and reduce fatigue, which indirectly helps activity and adherence