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While evidence suggests GLP-1 receptor agonists have protective effects against arterial disease, the evidence specifically examining venous thrombosis risk is more limited, though no safety signals have emerged

"Metabolic flexibility in health and disease." Cell metabolism 25.5 (2017): 1027-1036

The UK product information notes that semaglutide caused C-cell tumours in rodents (though the human relevance is uncertain) and advises monitoring for thyroid symptoms, especially with pre-existing thyroid disease

For instance, studies have observed a significant reduction of wrinkle volume, with some research indicating reductions of over 30% compared to other active compounds and over 50% compared to control serum

C., Heine, T