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Glutathione reverses the growth abnormalities of skin fibroblasts from insulin-dependent diabetic patients with nephropathy

JAMA Neurol 2013

Rapid reduction or abrupt discontinuation of opioid analgesics in patients who are physically dependent on opioids has resulted in serious withdrawal symptoms, uncontrolled pain, and suicide

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In some cases, symptoms precede the classical neurological signs by up to several months, suggesting that digestive dysfunction may, in fact, be an early indicator of TD before progressing to other bodily systems