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Users start with a low dose of these medications and gradually increase it over time until they reach a targeted dose

Weight regain after stopping semaglutide or tirzepatide is a real concern

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(21) In the context of significant weight loss, reduced skeletal loading may lead to an imbalance favoring osteoclastic activity and bone resorption, which could explain the decreased BMD observed in semaglutide-treated patients

For example, the mechanism of action of GLP-1R in non-islet function is not fully understood and further studies are needed to elucidate it