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Interestingly, the incubation with the antioxidant N-acetylcysteine (NAC) upon treatment with NP4 resulted in reduced levels of apoptosis, suggestive that the cytotoxicity of NP4 is related to intracellular redox homeostasis (Supplementary Fig

How Glutathione Protects Cells from Oxidative Stress Oxidative stress is a contributing factor in numerous health issues, including cardiovascular diseases, neurodegenerative disorders, and certain cancers

coli is difficult, the cooperation between ATP generation and glutathione synthesis seemed to be inefficient

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After 60 s, trophozoite stage parasites (here shown for the 3D7 strain) expressing hGrx1-roGFP2 were treated with 10 mM DTT and monitored for 4 min