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Nadolsky says that for some of his patients at the highest dose of tirzepatide, the drug is sometimes "dampening that dopamine reward system down so much that now, instead of just getting away from those addictive behaviors, they don't feel like doing anything." Some of those high-dose patients start seeking out sugar, not due to cravings, he says, but because their bodies are searching for some kind of stimulation to get the reward system going again

That means a doctor has to confirm it meets specific medical rules

This can cause symptoms such as swelling, increased blood pressure, or electrolyte imbalances, which may stress the kidneys further

Initial studies of bremelanotide (a metabolite of MT-II) performed with intranasal dosing showed that bremelanotide induced an increase in sexual desire and improvement in satisfaction from sex [23]

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